Article

Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysm

2025-02-17

Abstract excerpt

<h4>Aim</h4> Reconstructive surgery is a life-saving treatment for individuals with advanced thoracic aortic aneurysms (TAAs) at risk of rupture. No effective pharmacological treatments are available to halt aortic dilatation before it reaches this critical point. Unravelling the cellular and molecular pathways involved in TAA formation and expansion is fundamental for identifying potential treatment targets. Thi...

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Literature Corpus work: d9e9273c-90ff-508c-b0c0-a3a83a10b447
DOI: 10.1101/2025.02.16.638506

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