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Article

Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Juul-Madsen Kristian, Rudolph Ina-Maria, Gomes Jemila P, Meyer Katrina, Ovesen Peter L, Gorniak-Walas Malgorzata, Kokoli Marianna, Telugu Narasimha S, von Tangen Sivertsen Malthe, Febbraro Fabia, Sutherland Duncan S, Palmfeldt Johan, Diecke Sebastian, Andersen Olav M, Selbach Matthias, Willnow Thomas E

Abstract excerpt

INTRODUCTION: Mutations in SORL1, encoding the sorting receptor Sortilin-related receptor with A-type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLAN1358S, carrying a mutation in its ligand binding domain, to learn more about receptor functions relevant for human brain health. METHODS: We investigated consequences of SORLAN1358S expression in induced pluripotent stem...

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Identifiers

PMID: 40928027
DOI: 10.1002/alz.70591
PMCID: PMC12421412

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.PMID 40928027Read ↗

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