INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

Abstract excerpt

The Integrator complex processes 3'-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription of protein coding genes by terminating transcription after unstable pausing. The molecular basis for Integrator's functions remains obscure. Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a...

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• Ku Autoantigen
• Nucleic Acid Conformation
• Nucleic Acids
• Protein Domains
• Protein Multimerization