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Article

Assembly mechanism of Integrator's RNA cleavage module.

Molecular cell - 8 Aug 2024

Sabath Kevin, Qiu Chunhong, Jonas Stefanie

Abstract excerpt

The modular Integrator complex is a transcription regulator that is essential for embryonic development. It attenuates coding gene expression via premature transcription termination and performs 3'-processing of non-coding RNAs. For both activities, Integrator requires endonuclease activity that is harbored by an RNA cleavage module consisting of INTS4-9-11. How correct assembly of Integrator modules is achieved...

Topics

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Catalytic Domain
Cell Nucleus
HEK293 Cells
Mutation
Phytic Acid
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Nucleotidyltransferases

Source

Identifiers

PMID: 39032489
DOI: 10.1016/j.molcel.2024.06.032

Genes

BRAT1
INTS4
INTS9
INTS11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Assembly mechanism of Integrator's RNA cleavage module.PMID 39032489Read ↗

Inositol hexakisphosphate is a critical regulator of Integrator assembly and functionSemantic proximity Read ↗

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.Semantic proximity Read ↗

BRAT1 links Integrator and defective RNA processing with neurodegeneration.Semantic proximity Read ↗

Human mutations in integrator complex subunits link transcriptome integrity to brain development.Semantic proximity Read ↗

<i>INTS13</i> Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex AssemblySemantic proximity Read ↗

Integrator loss leads to dsRNA formation that triggers the integrated stress response.Semantic proximity Read ↗

INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II ComplexesSemantic proximity Read ↗

Unprocessed U1 snRNAs as a biomarker of INTS11- and BRAT1-related neurodevelopmental disorders.Semantic proximity Read ↗

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.Semantic proximity Read ↗

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.Semantic proximity Read ↗

BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genesSemantic proximity Read ↗

A role for the <i>C. elegans</i> Argonaute protein CSR-1b isoform in small nuclear RNA 3’ processingSemantic proximity Read ↗

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