Article

Integrator terminates promoter-proximal Pol II to generate <i>C. elegans</i> piRNA precursors

2020-05-02

Abstract excerpt

Piwi-interacting RNAs (piRNAs) play key roles in germline development and genome defence in metazoans. In C. elegans , piRNAs are transcribed from >15000 discrete genomic loci by RNA polymerase II, resulting in 28 nt short-capped piRNA precursors. Here we investigate transcription termination at piRNA loci. We show that the Integrator complex, which terminates snRNA transcription, is recruited to piRNA loci. We s...

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Literature Corpus work: 82cc9b1b-8ad8-5ea6-981e-7d425fc0aab5
DOI: 10.1101/2020.05.01.072298

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