Article

Inositol hexakisphosphate is a critical regulator of Integrator assembly and function

2021-09-14

Abstract excerpt

Integrator has critical roles in noncoding RNA 3′-end processing as well as transcription attenuation of selected mRNAs. IntS11 is the endonuclease for RNA cleavage, as a part of the IntS4-IntS9-IntS11 complex (Integrator cleavage module, ICM). Our structure of the Drosophila ICM, determined by cryo-electron microscopy at 2.74 Å resolution, unexpectedly revealed the stable association of an inositol hexakisphosph...

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Literature Corpus work: d9c72426-9695-55be-bd8c-a5b1bfdd30f9
DOI: 10.1101/2021.09.14.460315

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