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Article

Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex.

International journal of molecular sciences - 29 Apr 2017

Federico Antonio, Rienzo Monica, Abbondanza Ciro, Costa Valerio, Ciccodicola Alfredo, Casamassimi Amelia

Abstract excerpt

The integrator complex has been recently identified as a key regulator of RNA Polymerase II-mediated transcription, with many functions including the processing of small nuclear RNAs, the pause-release and elongation of polymerase during the transcription of protein coding genes, and the biogenesis of enhancer derived transcripts. Moreover, some of its components also play a role in genome maintenance. Thus, it...

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Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Genomics
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Subunits

Transcription, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 28468258
DOI: 10.3390/ijms18050936
PMCID: PMC5454849

Genes

INTS7
INTS8
INTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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