Article

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel

2026-05-18

Abstract excerpt

<h4>Background and Objectives</h4> Intravesical gemcitabine/docetaxel (Gem/Doce) is an effective therapy for Bacillus Calmette– Guérin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC), achieving 50% complete responses at 2 years. However, the genomic determinants underlying response and resistance to Gem/Doce remain poorly defined. Our objective was to define the mutational landscape of BCG-unrespons...

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Literature Corpus work: 893747cd-8c0c-5f0c-8786-8eadb131b412
DOI: 10.64898/2026.05.10.724123

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