Article
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer.
Nature communications - 19 Dec 2017
Liu David, Abbosh Philip, Keliher Daniel, Reardon Brendan, Miao Diana, Mouw Kent, Weiner-Taylor Amaro, Wankowicz Stephanie, Han Garam, Teo Min Yuen, Cipolla Catharine, Kim Jaegil, Iyer Gopa, Al-Ahmadie Hikmat, Dulaimi Essel, Chen David Y T, Alpaugh R Katherine, Hoffman-Censits Jean, Garraway Levi A, Getz Gad, Carter Scott L, Bellmunt Joaquim, Plimack Elizabeth R, Rosenberg Jonathan E, Van Allen Eliezer M
Abstract excerpt
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matched pre- and post-neoadjuvant cisplatin-based chemotherapy primary bladder tumor samples from 30 muscle-invasive bladder cancer patients. We observe no overall increase in tumor mutational burden...
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