Article
Genomic and Therapeutic Landscape of Non-muscle-invasive Bladder Cancer.
The Urologic clinics of North America - 1 Feb 2020
Cooley Lauren Folgosa, McLaughlin Kimberly A, Meeks Joshua J
Abstract excerpt
Non-muscle-invasive bladder cancer (NMIBC) is heterogeneous, but current diagnostic and treatment strategies rely primarily on clinical parameters, lacking individualization to tumor and host genetics and biology. The heterogeneity of NMIBCs is derived from mutations, mutation signatures, chromosomal loss, and disruption of molecular pathways, which ultimately affects tumor progression, recurrence, and...
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