Article
Genomic characterization of high-risk non-muscle invasive bladder cancer.
Oncotarget - 15 Nov 2016
Meeks Joshua J, Carneiro Benedito A, Pai Sachin G, Oberlin Daniel T, Rademaker Alfred, Fedorchak Kyle, Balasubramanian Sohail, Elvin Julia, Beaubier Nike, Giles Francis J
Abstract excerpt
The genetic mechanisms associated with progression of high-risk non-muscle-invasive bladder cancer (HR-NMIBC) have not been described. We conducted selective next-generation sequencing (NGS) of HR-NMIBC and compared the genomic profiles of cancers that responded to intravesical therapy and those that progressed to muscle-invasive or advanced disease. DNA was extracted from paraffin-embedded sections from 25...
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