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Article

Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis.

Nature communications - 25 Sept 2020

Taber Ann, Christensen Emil, Lamy Philippe, Nordentoft Iver, Prip Frederik, Lindskrog Sia Viborg, Birkenkamp-Demtröder Karin, Okholm Trine Line Hauge, Knudsen Michael, Pedersen Jakob Skou, Steiniche Torben, Agerbæk Mads, Jensen Jørgen Bjerggaard, Dyrskjøt Lars

Abstract excerpt

Overtreatment with cisplatin-based chemotherapy is a major issue in the management of muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for predicting response have been implemented in the clinic. Here we perform a comprehensive multi-omics analysis (genomics, transcriptomics, epigenomics and proteomics) of 300 MIBC patients treated with chemotherapy (neoadjuvant or first-line)...

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Identifiers

PMID: 32978382
DOI: 10.1038/s41467-020-18640-0
PMCID: PMC7519650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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