diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling

Abstract excerpt

<h4>ABSTRACT</h4> Protein-protein interactions (PPIs) underlie most biological functions. Devastating human conditions like cancers, neurological disorders, and infections, hijack PPI networks to initiate disease, and to drive disease progression. Understanding precisely how diseases remodel PPI networks can, therefore, help clarify disease mechanisms and identify therapeutic targets. Protein kinases control most...

Topics

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• Cancer-related Molecular Pathways
• Cellular transport and secretion
• Microtubule and mitosis dynamics
• Mutation
• Phosphorylation
• Protein Kinase Inhibitors
• Protein Kinase Regulation and GTPase Signaling
• Protein Kinases

Identifiers and source

Literature Corpus work

5b7ae60f-56e1-59ea-a7a5-67dd0771e12a

DOI

10.1101/2024.11.22.624841