Motif-based phosphoproteome clustering improves modeling and interpretation

Abstract excerpt

Cell signaling is orchestrated in part through a network of protein kinases and phosphatases. Dysregulation of kinase signaling is widespread in diseases such as cancer and is readily targetable through inhibitors of kinase enzymatic activity. Mass spectrometry-based analysis of kinase signaling can provide a global view of kinase signaling regulation but making sense of these data is complicated by its stochastic...

Topics

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• Bioinformatics and Genomic Networks
• Carcinoma, Non-Small-Cell Lung
• Enzyme Inhibitors
• Multivariate Analysis
• Phosphorylation
• Protein-Tyrosine Kinases
• Reproducibility of Results
• Software

Identifiers and source

Literature Corpus work

76953b9b-281e-5349-bcad-72e175f26e3f

DOI

10.1101/2021.06.09.447799