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Article

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.

Cancer research - 1 Jan 2018

Wilson Leah J, Linley Adam, Hammond Dean E, Hood Fiona E, Coulson Judy M, MacEwan David J, Ross Sarah J, Slupsky Joseph R, Smith Paul D, Eyers Patrick A, Prior Ian A

Abstract excerpt

The human protein kinome comprises 535 proteins that, with the exception of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation of multiple protein substrates. While a major research focus of the last 30 years has been cancer-associated Tyr and Ser/Thr kinases, over 85% of the kinome has been identified to be dysregulated in at least one disease or...

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Identifiers

PMID: 29254998
DOI: 10.1158/0008-5472.CAN-17-2291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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