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Article

An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

Cancer research - 1 Apr 2016

Olow Aleksandra, Chen Zhongzhong, Niedner R Hannes, Wolf Denise M, Yau Christina, Pankov Aleksandr, Lee Evelyn Pei Rong, Brown-Swigart Lamorna, van 't Veer Laura J, Coppé Jean-Philippe

Abstract excerpt

Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circuits may therefore help elucidate mechanisms of response and resistance to kinase inhibitor therapies. In this study, we identified and validated phosphorylatable...

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Identifiers

PMID: 26921330
DOI: 10.1158/0008-5472.CAN-15-2325-T
PMCID: PMC4907268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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