Article

2,6-diaminopurine enhances Aqp4 stop codon readthrough and <i>AQP4</i> perivascular localization in the brain

2026-07-30

Abstract excerpt

<h4>ABSTRACT</h4> In the brain, the water channel Aquaporin 4 (AQP4) is largely restricted to astrocytes, enriched at perivascular astrocytic processes, and involved in fluid balance and neurological disease. The perivascular pool is functionally unique as it is depolarized in diseases, targeted by neuromyelitis optica autoantibodies, and implicated in the clearance of brain metabolites such as amyloid beta. The...

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Literature Corpus work: 892312b8-0faa-5b04-ab40-11a23a195ebb
DOI: 10.64898/2026.07.27.741080

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