Article

Identification of compounds enhancing <i>Aqp4</i> stop codon readthrough

2020-11-02

Abstract excerpt

An unusual stop codon readthrough event generates a conserved C-terminally elongated variant of the water channel protein Aquaporin 4 (AQP4). In the brain, AQP4 is astrocyte-specific, required for normal functioning of the glymphatic system, and involved in the clearance of the Alzheimer’s associated protein Amyloid beta. Further, the readthrough variant is localized exclusively perivascularly, and the perivascula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e076eb81-1aba-5b1e-ad51-c59d0bf28713
DOI: 10.1101/2020.11.01.363945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of compounds enhancing <i>Aqp4</i> stop codon readthroughDOI 10.1101/2020.11.01.363945Read

Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brainSemantic proximity Read

2,6-diaminopurine enhances Aqp4 stop codon readthrough and <i>AQP4</i> perivascular localization in the brainSemantic proximity Read

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codonsSemantic proximity Read

Identification of novel small molecule compounds with readthrough activity in Nagashima-type palmoplantar keratosis.Semantic proximity Read

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination CodonsSemantic proximity Read

Readthrough compounds for nonsense mutations: bridging the translational gap.Semantic proximity Read

Deciphering the molecular mechanism of stop codon readthroughSemantic proximity Read

Aminoglycoside-induced premature termination codon readthrough of <i>COL4A5</i> nonsense mutations that cause Alport syndromeSemantic proximity Read

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small moleculesSemantic proximity Read

Ataluren Suppresses a Premature Termination Codon in an MPS I-H MouseSemantic proximity Read

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiencySemantic proximity Read

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletionSemantic proximity Read