Article

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

2022-07-29

Abstract excerpt

<h4>ABSTRACT</h4> The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately establishing directional clearance of interstitial solutes. CSF transport is facilitated by the expression of aquaporin-4 (AQP4) water channels on the perivascular endfeet of astrocytes. Mice with genetic delet...

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Literature Corpus work: ce5d311e-e9a9-5b20-95de-53963bd43506
DOI: 10.1101/2022.07.27.501409

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