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Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis <i>in vivo</i>

9 Jan 2008

Abstract excerpt

Acute hyperammonemia (HA) causes cerebral edema and brain damage in children with urea cycle disorders (UCDs) and in patients in acute liver failure. Chronic HA is associated with developmental delay and mental retardation in children with UCDs, and with neuropsychiatric symptoms in patients with chronic liver failure. Astrocytes are a major cellular target of hyperammonemic encephalopathy, and changes occurring...

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PMID: 18186079
DOI: 10.1002/glia.20624

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