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Article

Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain

18 Aug 2022

Abstract excerpt

Alzheimer's disease is initiated by the toxic aggregation of amyloid-β. Immunotherapeutics aimed at reducing amyloid beta are in clinical trials but with very limited success to date. Identification of orthogonal approaches for clearing amyloid beta may complement these approaches for treating Alzheimer's disease. In the brain, the astrocytic water channel Aquaporin 4 is involved in clearance of amyloid beta, and...

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PMID: 36001414
DOI: 10.1093/brain/awac199

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