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Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations.

Experimental hematology - 1 Jul 2022

Kellaway Sophie G, Coleman Daniel J L, Cockerill Peter N, Raghavan Manoj, Bonifer Constanze

Abstract excerpt

The transcription factor RUNX1 is essential for correct hematopoietic development; in its absence in the germ line, blood stem cells are not formed. RUNX1 orchestrates dramatic changes in the chromatin landscape at the onset of stem cell formation, which set the stage for both stem self-renewal and further differentiation. However, once blood stem cells are formed, the mutation of the RUNX1 gene is not lethal but...

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PMID: 35341804
DOI: 10.1016/j.exphem.2022.03.009

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