Article
Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia.
Blood - 22 Oct 2020
Matsumura Takayoshi, Nakamura-Ishizu Ayako, Muddineni Siva Sai Naga Anurag, Tan Darren Qiancheng, Wang Chelsia Qiuxia, Tokunaga Kenji, Tirado-Magallanes Roberto, Sian Stephanie, Benoukraf Touati, Okuda Tsukasa, Asou Norio, Matsuoka Masao, Osato Motomi, Suda Toshio
Abstract excerpt
RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negative suppression of RUNX1 function is found in myelodysplastic syndrome and acute myeloid leukemia (AML). How posttranslational modifications (PTMs) of RUNX1 affect its in vivo function, however, and whether PTM dysregulation of RUNX1 can cause leukemia are largely unknown. We performed targeted deep sequencing on a...
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