Article

Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia

2026-05-06

Abstract excerpt

Aberrant activation of TAL1 , a key oncogenic driver, defines a major subgroup comprising ∼30% of childhood T-lineage acute lymphoblastic leukemias (T-ALLs). We and others have shown that somatic non-coding mutations within upstream and intronic cis -regulatory regions of TAL1 contribute to transformation by creating binding sites for MYB and other transcription factors. Here we investigated cis -regulatory me...

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Literature Corpus work: 315d709e-81dd-5e65-bf04-168f06bb716b
DOI: 10.64898/2026.05.03.722504

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