Article
Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia.
Cancer cell - 14 May 2018
Churchman Michelle L, Qian Maoxiang, Te Kronnie Geertruy, Zhang Ranran, Yang Wenjian, Zhang Hui, Lana Tobia, Tedrick Paige, Baskin Rebekah, Verbist Katherine, Peters Jennifer L, Devidas Meenakshi, Larsen Eric, Moore Ian M, Gu Zhaohui, Qu Chunxu, Yoshihara Hiroki, Porter Shaina N, Pruett-Miller Shondra M, Wu Gang, Raetz Elizabeth, Martin Paul L, Bowman W Paul, Winick Naomi, Mardis Elaine, Fulton Robert, Stanulla Martin, Evans William E, Relling Mary V, Pui Ching-Hon, Hunger Stephen P, Loh Mignon L, Handgretinger Rupert, Nichols Kim E, Yang Jun J, Mullighan Charles G
Abstract excerpt
Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causing aberrant cell-cell and cell-stroma interaction, and decreased sensitivity to tyrosine kinase...
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