Article

EZH2 inactivation drives MAPK-dependent vulnerability to MEK inhibition in RAS-mutant CMML

2026-06-04

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a heterogeneous hematologic malignancy with limited therapeutic options. Although RAS and RAS -modifying mutations ( RAS mut ) are common and associated with poor prognosis, targeting RAS signaling has shown limited clinical success. Here, we define co-occurrence of RAS mut and EZH2 inactivation ( EZH2 inact ) as a distinct molecular subgroup of CMML characterize...

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Literature Corpus work: 89079dcb-855e-54aa-9b15-e6712373a1d1
DOI: 10.64898/2026.06.02.729524

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