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Article

Loss of Ezh2 precipitates lethal disease progression in a mouse model of Calr-mutated myeloproliferative neoplasms.

Experimental hematology - 1 Mar 2026

Ueda Koki, Sato Yuka, Minakawa Keiji, Miura Saori, Hashimoto Yuko, Ikeda Kazuhiko

Abstract excerpt

Patients with CALR-mutant essential thrombocythemia (ET), the myeloproliferative neoplasm (MPN) subtype with the most favorable long-term prognosis, remain at risk of developing secondary myelofibrosis (sMF) or acute myeloid leukemia (AML). Outcomes after such progression are poor. Loss-of-function mutations in the epigenetic regulator EZH2 are frequently acquired during disease evolution, but their causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41397566
DOI: 10.1016/j.exphem.2025.105350

Genes

CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Loss of Ezh2 precipitates lethal disease progression in a mouse model of Calr-mutated myeloproliferative neoplasms.PMID 41397566Read ↗

Loss of <i>Ezh2</i> synergizes with <i>JAK2</i> -V617F in initiating myeloproliferative neoplasms and promoting myelofibrosisSemantic proximity Read ↗

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Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read ↗

Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasmSemantic proximity Read ↗

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemiaSemantic proximity Read ↗

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AMLSemantic proximity Read ↗

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent mannerSemantic proximity Read ↗

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibitionSemantic proximity Read ↗

Mouse models of human AML accurately predict chemotherapy response.Semantic proximity Read ↗

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