Article

<i>RAS</i> mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axis

2019-12-26

Abstract excerpt

<h4> ABSTRACT </h4> Chronic myelomonocytic leukemia (CMML) is an aggressive hematological malignancy with limited treatment options. Whole exome (WES) and targeted sequencing of several independent cohorts of CMML patients, comparing dysplastic (dCMML) to proliferative (pCMML) CMML, as well as paired chronic phase disease and acute leukemic transformation (LT), associate acquisition of oncogenic RAS pathway muta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21bd81e9-cb66-54d1-ad4e-4c0ef2f429da
DOI: 10.1101/2019.12.23.874487

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>RAS</i> mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axisDOI 10.1101/2019.12.23.874487Read

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.Semantic proximity Read

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in <i>RAS</i> -mutated chronic myelomonocytic leukemiaSemantic proximity Read

Chronic myelomonocytic leukemia with double activating <i>KRAS</i> mutations: molecular characterization of an uncommon caseSemantic proximity Read

Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.Semantic proximity Read

Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia.Semantic proximity Read

Chronic myelomonocytic leukemia: myeloproliferative variant.Semantic proximity Read

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.Semantic proximity Read

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Semantic proximity Read

Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment.Semantic proximity Read

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.Semantic proximity Read

EZH2 inactivation drives MAPK-dependent vulnerability to MEK inhibition in RAS-mutant CMMLSemantic proximity Read

In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic VulnerabilitiesSemantic proximity Read