Article

<i>RAS</i> -mutant clones drive extramedullary acute myeloid leukemia

2026-04-09

Abstract excerpt

Extramedullary acute myeloid leukemia (eAML) represents a clinically challenging manifestation of acute myeloid leukemia (AML), but its molecular drivers remain poorly defined. We performed targeted sequencing in 85 eAML biopsies, representing one of the largest molecular analyses of eAML to date. We detected mutations in RAS or RAS -modifying genes ( RAS MUT ; NRAS, KRAS, PTPN11, CBL , and NF1 ) in 41% of ca...

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Literature Corpus work: 37a20df4-face-596d-80d4-dbfc5db8fb62
DOI: 10.64898/2026.04.07.715220

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