Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

doi:10.1158/2159-8290.CD-16-1032

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Article

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

Cancer discovery - 1 Aug 2017

Glass Jacob L, Hassane Duane, Wouters Bas J, Kunimoto Hiroyoshi, Avellino Roberto, Garrett-Bakelman Francine E, Guryanova Olga A, Bowman Robert, Redlich Shira, Intlekofer Andrew M, Meydan Cem, Qin Tingting, Fall Mame, Alonso Alicia, Guzman Monica L, Valk Peter J M, Thompson Craig B, Levine Ross, Elemento Olivier, Delwel Ruud, Melnick Ari, Figueroa Maria E

Abstract excerpt

We performed cytosine methylation sequencing on genetically diverse patients with acute myeloid leukemia (AML) and found leukemic DNA methylation patterning is primarily driven by nonpromoter regulatory elements and CpG shores. Enhancers displayed stronger differential methylation than promoters, consisting predominantly of hypomethylation. AMLs with dominant hypermethylation featured greater epigenetic...

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Identifiers

PMID: 28408400
DOI: 10.1158/2159-8290.CD-16-1032
PMCID: PMC5540802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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