Article
EZH2-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress.
Cancer discovery - 1 Jul 2020
León Theresa E, Rapoz-D'Silva Tanya, Bertoli Cosetta, Rahman Sunniyat, Magnussen Michael, Philip Brian, Farah Nadine, Richardson Simon E, Ahrabi Sara, Guerra-Assunção José Afonso, Gupta Rajeev, Nacheva Elisabeth P, Henderson Stephen, Herrero Javier, Linch David C, de Bruin Robertus A M, Mansour Marc R
Abstract excerpt
Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Using isogenic T-ALL cells, with and without CRISPR/Cas9-induced EZH2-inactivating mutations, we performed a cell-based synthetic lethal drug screen. EZH2-deficient cells exhibited increased sensitivity to structurally diverse...
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