Article

IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding

2022-09-28

Abstract excerpt

The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of viruses. Here we evaluated a panel of human influenza virus monoclonal antibodies (mAbs) expressed as IgG1, IgG2 or IgG3. We found that many influenza virus-specific mAbs have altered binding and neutralization capacity depending on the IgG subclass encoded, and that th...

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Literature Corpus work: 2b2e81ca-9156-52bb-a07e-36e22c375352
DOI: 10.1101/2022.09.27.509738

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IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent bindingDOI 10.1101/2022.09.27.509738Read

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