Article

SETD2 maintains nuclear lamina stability to safeguard the genome

2023-09-29

Abstract excerpt

Histone methyltransferases play essential roles in the organization and function of chromatin. They are also frequently mutated in human diseases including cancer 1 . One such often mutated methyltransferase, SETD2, associates co-transcriptionally with RNA polymerase II and catalyzes histone H3 lysine 36 trimethylation (H3K36me3) – a modification that contributes to gene transcription, splicing, and DNA repair 2...

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Literature Corpus work: 35e76600-fefa-59f1-b892-b9acede5ccdd
DOI: 10.1101/2023.09.28.560032

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