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Article

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

14 May 2018

Abstract excerpt

MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related...

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PMID: 29777171
DOI: 10.1038/s41467-018-04329-y

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