Impaired oxidative phosphorylation drives primary tumor escape and metastasis

Abstract excerpt

<h4>Summary</h4> Metastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer cells to detach from neighboring cells, become migratory, and escape the primary tumor. While different phases of metastasis expose cells to variable nutrient environments and...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Carcinogenesis
• Electron Transport
• Mitochondria
• Mitochondrial Function and Pathology
• Mutation
• Neoplasm Metastasis

Identifiers and source

Literature Corpus work

88857143-57cc-55d1-9081-59eb9c325baa

DOI

10.1101/2025.01.08.631936