Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.

doi:10.1126/scisignal.abc4436

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Article

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.

Science signaling - 5 Jan 2021

Crooks Daniel R, Maio Nunziata, Lang Martin, Ricketts Christopher J, Vocke Cathy D, Gurram Sandeep, Turan Sevilay, Kim Yun-Young, Cawthon G Mariah, Sohelian Ferri, De Val Natalia, Pfeiffer Ruth M, Jailwala Parthav, Tandon Mayank, Tran Bao, Fan Teresa W-M, Lane Andrew N, Ried Thomas, Wangsa Darawalee, Malayeri Ashkan A, Merino Maria J, Yang Youfeng, Meier Jordan L, Ball Mark W, Rouault Tracey A, Srinivasan Ramaprasad, Linehan W Marston

Abstract excerpt

Understanding the mechanisms of the Warburg shift to aerobic glycolysis is critical to defining the metabolic basis of cancer. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an aggressive cancer characterized by biallelic inactivation of the gene encoding the Krebs cycle enzyme fumarate hydratase, an early shift to aerobic glycolysis, and rapid metastasis. We observed impairment of the...

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Identifiers

PMID: 33402335
DOI: 10.1126/scisignal.abc4436
PMCID: PMC8039187

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