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Mitochondrial complex I promotes kidney cancer metastasis

14 Aug 2024

Abstract excerpt

Abstract Most kidney cancers are metabolically dysfunctional 1–4 , but how this dysfunction affects cancer progression in humans is unknown. We infused 13 C-labelled nutrients in over 80 patients with kidney cancer during surgical tumour resection. Labelling from [U- 13 C]glucose varies across subtypes, indicating that the kidney environment alone cannot account for all tumour metabolic reprogramming. Compared...

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PMID: 39143213
DOI: 10.1038/s41586-024-07812-3

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