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Article

New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2015

Srinivasan Ramaprasad, Ricketts Christopher J, Sourbier Carole, Linehan W Marston

Abstract excerpt

The development of new forms of treatment of advanced renal cell carcinoma over the past two decades has been primarily focused on targeting the VHL/HIF pathway. The recent identification of mutations of chromatin-remodeling genes in clear-cell renal carcinoma (ccRCC), of genomic heterogeneity, and of a Warburg-like metabolic phenotype in advanced disease has had a profound effect on our understanding of the...

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Share to Carcinoma, Renal Cell
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Metabolic Networks and Pathways

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Share to NF-E2-Related Factor 2

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Source

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Identifiers

PMID: 25564569
DOI: 10.1158/1078-0432.CCR-13-2993
PMCID: PMC4795462

Genes

CUL3
HGF
KEAP1
MET
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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