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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

21 Oct 2021

Abstract excerpt

BACKGROUND: Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. RESULTS: We constructed loss-of-function mutants of NDPK-D, lacking either NDP kinase activity or membrane interaction and expressed mutants or wild-type protein in cancer cells. In a complementary approach, we performed depletion of...

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PMID: 34674701
DOI: 10.1186/s12915-021-01155-5

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