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Structure–function coupling changes in first-episode, treatment-naïve schizophrenia correlate with cell type-specific transcriptional signature

23 Oct 2024

Abstract excerpt

BACKGROUND: First-episode schizophrenia (FES) is a complex and progressive psychiatric disorder. The etiology of FES involves genetic, environmental, and neurobiological factors. This study investigates the association between alterations in structural-functional (SC-FC) coupling and transcriptional expression in FES. METHODS: This study encompassed a cohort of 214 participants, comprising 111 FES patients and...

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PMID: 39443976
DOI: 10.1186/s12916-024-03714-3

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