Article

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD

2026-07-14

Abstract excerpt

Frontotemporal dementia (FTD) is characterized by selective neuronal vulnerability, yet the features that predispose specific neuron types to degeneration remain unclear. We performed single-nucleus RNA sequencing of frontoinsular cortex, a region affected early in behavioral variant FTD, across individuals with C9orf72 -associated and sporadic FTD-MND spectrum disease. By enriching for large projection neurons,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c31102fb-d2fc-554b-99fd-f3e3c425b5da
DOI: 10.64898/2026.07.13.738307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTDDOI 10.64898/2026.07.13.738307Read

Single-cell profiling of the human primary motor cortex in ALS and FTLDSemantic proximity Read

Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation.Semantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrumSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s DementiaSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell statesSemantic proximity Read

The Alzheimer’s disease neurodegenerative cascade reconstructed in human L2/3 excitatory neuronsSemantic proximity Read

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neuronsSemantic proximity Read

Transcriptional Patterns in Stages of Alzheimer's Disease Are Cell-Type–Specific and Partially Converge with the Effects of Alcohol Use Disorder in HumansSemantic proximity Read

Divergent impacts of <i>C9orf72</i> repeat expansion on neurons and glia in ALS and FTDSemantic proximity Read