Cellular and circuit excitability in rodent models of neurodevelopmental disorders

Abstract excerpt

Autism spectrum disorders and intellectual disabilities (ASD/ID) are estimated to a↵ect approximately 3-5% of the population. Genetic factors constitute a major risk factor in ASD/ID, accounting for 40 to 50% of cases, with monogenic forms of syndromic ASD representing 5% of cases. Many of the genetic causes of ASD/ID are thought to share common phenotypes at the cellular level, thus animal models of monogenic for...

Topics

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• Allosteric Regulation
• Antipsychotic Agents
• Child Development Disorders, Pervasive
• Disease Models, Animal
• Mice
• Neuronal Plasticity
• Receptor, Metabotropic Glutamate 5
• Synapses

Identifiers and source

Literature Corpus work

594736f8-dbc9-5c43-a3d3-db37694dfd25

DOI

10.7488/era/1314