Article

FMRP sustains presynaptic function via control of activity-dependent bulk endocytosis

2020-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Synaptic vesicle (SV) recycling defects are linked to neurodevelopmental disorders, including fragile X syndrome (FXS), which results from loss of fragile X mental retardation protein (FMRP) encoded by the FMR1 gene. Hyperexcitability of neuronal circuits is a key feature of FXS, therefore we investigated whether SV recycling was affected by the absence of FMRP during increased neuronal activit...

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Literature Corpus work: 61dff27d-12d9-5a75-b12e-3c59ab3ed1d6
DOI: 10.1101/2020.09.10.291062

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