Article

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

2024-10-17

Abstract excerpt

<h4>SUMMARY</h4> Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful mutations. However, the reconstitution of mtDNA deletions responsible for severe mitochondrial myopathies and age-related diseases has not yet been achieved in human cells. Here, we developed a method to eng...

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Literature Corpus work: 93a42c72-36cf-5489-9bdc-afd146ca25da
DOI: 10.1101/2024.10.15.618543

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