Article
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease
2022-06-23
Abstract excerpt
Age-associated microglial dysfunction contributes to the accumulation of amyloid-b (Ab) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few have examined phagocytosis of normally aged microglia. Furthermore, much of the existing data on aging microglial function have been generated in accelerated genetic models of Alzh...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- be24664a-ca38-5d1c-b715-8278c6ac341c
- DOI
- 10.21203/rs.3.rs-1720794/v1