Article

Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis

2025-10-30

Abstract excerpt

Obesity-associated inflammation disrupts pancreatic β-cell function, but the immune-derived signals that directly regulate insulin secretion remain incompletely defined. Here, we identify myeloid Gq signaling as a critical immunometabolic node that links macrophage activation to β-cell dysfunction. For the first time, we employed a chemogenetic approach (DREADDs) to selectively and temporally activate Gq-coupled G...

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Identifiers and source

Literature Corpus work: 8808b736-959c-56dc-89f2-5df201fd0016
DOI: 10.1101/2025.10.29.680858

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Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axisDOI 10.1101/2025.10.29.680858Read

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