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Article

GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9.

Nature metabolism - 1 Jan 2019

Mantelmacher Fernanda Dana, Zvibel Isabel, Cohen Keren, Epshtein Alona, Pasmanik-Chor Metsada, Vogl Thomas, Kuperman Yael, Weiss Shai, Drucker Daniel J, Varol Chen, Fishman Sigal

Abstract excerpt

Enteroendocrine cells relay energy-derived signals to immune cells to signal states of nutrient abundance and control immunometabolism. Emerging data suggest that the gut-derived nutrient-induced incretin glucose-dependent insulinotropic polypeptide (GIP) operates at the interface of metabolism and inflammation. Here we show that high-fat diet (HFD)-fed mice with immune cell-targeted GIP receptor (GIPR)...

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PMID: 32694806
DOI: 10.1038/s42255-018-0001-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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