Back to search

Article

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

2020-10-01

Abstract excerpt

<h4>Background</h4> Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. <h4>Results</h4> Here, we combined the notions of epipolymorphism and epiallele switching to analyze DNA methylation heterogeneity in MM patients. We show that MM is characterized by the continuo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6748360b-cc1f-56c0-913d-5ebba039289e
DOI
10.1101/2020.10.01.321943
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variabilityDOI 10.1101/2020.10.01.321943
Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple MyelomaSemantic proximity
DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity
DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity
Epigenetic reprogramming in multiple myeloma—Challenges and opportunitiesSemantic proximity
Dynamic super-enhancer core regulatory circuits and epigenetic landscapes drive malignant progression and refractory disease in multiple myelomaSemantic proximity
Genomic landscape of multiple myeloma and its precursor conditionsSemantic proximity
Genomic landscape and chronological reconstruction of driver events in multiple myelomaSemantic proximity
The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myelomaSemantic proximity
Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myelomaSemantic proximity
Methylation variability and LINE-1 activation in multiple myelomaSemantic proximity
Cutting edge genomics reveal new insights into tumour development, disease progression and therapeutic impacts in multiple myeloma.Semantic proximity
Genomic landscape and chronological reconstruction of driver events in multiple myelomaSemantic proximity
Select a neighboring publication to make it the new centre.