Article

MYB insufficiency disrupts proteostasis in hematopoietic stem cells leading to age-related neoplasia

2021-09-06

Abstract excerpt

<h4>ABSTRACT</h4> The Myb transcription factor plays critical roles in normal and malignant hematopoiesis. Acquired genetic dysregulation of Myb, which plays a central role in hematopoietic stem cell (HSC) gene regulation, is involved in the etiology of a number of leukemias. Also, inherited non-coding variants of the Myb gene are a factor in susceptibility to many hematological conditions, including myeloprolife...

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Literature Corpus work: 5d89b8f0-41b7-50fa-b0b1-935998508655
DOI: 10.1101/2021.09.04.458970

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