Article
MYST Acetyltransferases Interact with SETBP1 and Are a Targetable Therapeutic Vulnerability in SETBP1-Mutant Leukemia.
Blood cancer discovery - 1 Jul 2026
Carlson Hanqian L, Nguyen Thai T, Tauchmann Samantha, Carratt Sarah A, Kruer Traci L, Dankyi Nana Adjoa, Balasis Maria E, Kim Hyeyoon, Tsai Chia-Feng, Liu Tao, Shrestha Shawn B, Fischer Jared M, Padron Eric, Braun Theodore P, Maxson Julia E
Abstract excerpt
Mutations in SETBP1 are associated with adverse prognosis in myeloid malignancies. These mutations stabilize the SETBP1 protein, driving increased expression of a progenitor-associated gene expression program through incompletely described mechanisms. A proteomic screen revealed interactions between SETBP1 and MYST acetyltransferase complexes, including the catalytic subunits-KAT6A and KAT7. In cell line and...
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